Additionally, siege battles are often very unbalanced, giving one side an unfair advantage and making it impossible for the opposing side to either attack or defend. Bad AI affects both your own units and units of your opponents, for example pathfinding issues where the AI will not move in a normal direction. Unfortunately, Stronghold is plagued by a less-than-ideal AI system. The Steam update of Stronghold 2 also allows the sharing of maps and stronholds via the workshop. As in many strategy games, especially those released at the time, a level editor is available, allowing you to create playeable worlds. Beyond these two modes, there also exists a battle mode, where we play either the attackers or defenders of the stronghold. These two game systems can be played through two campaigns offered by the game. The path of war focuses more on the management and establishment of an army, in order to fight the opposing forces and destroy opposing strongholds. Those wishing to follow the path of peace will have to concentrate on the construction and management of their castle, ensuring the happiness of the occupants of the castle, good harvest of the various resources etc. These two modes give the player entirely different gameplay styles. A team of five players must work together to battle 10 waves of. Stronghold 2 offers the player two main game modes: the way of peace or war. Barbarian Assault is a safe team-based Combat minigame located at the Barbarian Outpost. Existing Steam owners can upgrade for free to the newly remastered version of the game, which includes new maps, enhanced visuals, Workshop support, and more. For example, an all-new recruiting center for mercenaries, a popularity system that is closely related to the activities of the lord and the castle, a more elaborate system of punishment to criminals, new forms of raw materials and new recruitable troops, as well as as new siege weapons. Stronghold 2 offers more content than its predecessors Stronghold and Stronghold Crusader. The game was developed by Firefly Studios and published by 2K Games. Exiting map editor and entering a game of Kingmaker will not fix this bug, and the black void will appear in-game. This void remains until the game is restarted. Games Stronghold This is the first version Stronghold: Crusader The second installment, Stronghold: Crusader, was released in September 2002. Simply, when a waterfall is placed too close to the edge of the map, any incline or change in terrain height is replaced with a black void. The Anno series and some of the younger Settler entries ("Settlers - Rise of an Empire" ?) could also be something to look at.Stronghold 2 is a strategy and management video game released in 2005 and running on Windows. Stronghold is a series of real-time strategy video games developed by Firefly Studios and set in medieval times. And "Diplomacy is not an option" could also be fun (more of a "They are Billions" style horde defense game, currently in early access). Restart your computer, install the game and then restart the computer again. I can kinda recommend "Kingdoms and Castles" (more chill-out city builder than RTS). Make sure the Stronghold 2 folder in My Documents is deleted. (Steam version + mods for modern resolutions). Even Age of Empires 2 is closer to Stronghold x] "Knights of honor" is more of a real time Total War, but the sieges can be quite nice. Also abandonware, so completely free as long as you get it to work on your system: "Medieval Lords" has great castle/city planning and economy elements, but battles and sieges control a bit awkwardly (you place down flags and squads move there, then attack by themselves). 30+ games like Stronghold 2 - SteamPeek Indie friendly game discovery If you'd like to promote your game here just send a letter to Stronghold 2 Search Include tags Exclude tags Top similar games like Stronghold 2: Updated on 2023. Again, janky as ♥♥♥♥, but can be really atmospheric. "Warrior Kings" (and the standalone second part "Warrior Kings - Battles". But economy is done on a world map in between battles/sieges, Total War style.ġ-2 are really old but gold, 3 is 3D and easier to play and closer to Stronghold 2, but rather buggy. This shows some very close ties to the original Stronghold, especially the siege mechanics and unit line-up. The new day and night cycles, plus the physics of collapsing buildings, are a stark contrast to largely drab graphics and some clipping problems. Wit a back to the roots approach, the game tries to avoid disgrace a la Stronghold 2. It's currently abandonware, so it is free if you can make it work on your system: Stronghold 3 is a successor that takes up the story of the original and continues it. It is quite close to the scale of Stronghold 2. If you can work with early 2k jankiness, maybe have a look at "Castle Strike". There are some older games that incorporate castle building and sieging (I played them all on a rather modern system and Win10, but it can require a bit of tinkering in files as well as luck):
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Sugar, Dried Corn Syrup, Non-Fat Milk Powder, Guar Gum, Carrageenan and Gum Arabic, Natural Vanilla Flavor with other Natural Flavors. Founding father Thomas Jeffersonwho is credited with creating the first. Food & Drug Administration still requires a minimum of 10 dairy fat in any product labeled ice cream. But in 2015, new guidelines eliminated those requirements. Nutrition Facts Serving Size: 28.0 g Servings per Container: 4 Energy The UK used to require that ice cream contain at least 5 dairy fat. Greased and floured a tube pan baked for about an hour and 20 mins. Then I added the eggs one at a time, then the milk, vanilla and flour, blending the flour one cup at a time. All natural and preservative-free, Junket ice cream mix is indulgent, wholesome and fun. First I creamed the butter and sugar together until smooth. Enjoy the delicious simplicity of creamy very vanilla ice cream mix or add your own touch by mixing in nuts, candy, or toppings. Make homemade ice cream quickly and easily with all natural Junket ice cream mix. Junket®, all natural, ice cream mix, gluten free, simply strawberry. Junket®, all natural, ice cream mix, gluten, dutch chocolate. Substitute reduced fat milk in place of the whole milk and cream. Return mixture to pan and freeze until firm. Put chunks into small bowl and beat with electric mixer until smooth (about 2 minutes). Pour mixture into 9" x 5" pan and freeze until firm. Best Sellers Rank: 472,694 in Grocery & Gourmet Food ( See Top 100 in Grocery & Gourmet Food) 161 in Condensed Milk. Put chunks into small bowl and beat with electric mixer until smooth (about 2. Product Dimensions : 3.31 x 3 x 3 inches 14.08 Ounces. Pour mixture into 9' x 5' pan and freeze until firm. Freeze according to manufacturer's instructions.Įasy ice cream without using an ice cream maker:Ĭombine contents of one (1) Junket ice cream mix package with 1 1/4 cups whole milk and 3/4 cup of heavy cream. Easy ice cream without using an ice cream maker: Combine contents of one (1) Junket ice cream mix package with 1 1/4 cups whole milk and 3/4 cup of heavy cream. Pour mixture into your home ice cream maker. To make two batches at once (1/2 gallon): double the ingredients as stated above.Ĭombine contents of one (1) Junket ice cream mix package with 1 1/4 cups of whole milk and 3/4 cups of heavy cream in a bowl. Junket ice cream mix, 1 1/4 cups of whole milk, 3/4 cup heavy whipping cream. What you need (yields 1 quart of ice cream):ġ pkg. Most other battery "Sudo-manufacturers" like Efest, MXJO, AWT, Eizfan, Beizen, etc buy up the B and C bin discards the big 4 won't put their name on and sell as authentics, re-wrap with the Sudo label with the PDR amp rating. The big 4 main battery manufacturers (LG, Sony, Samsung, Panasonic/Sanyo) on their authentic A Bin batteries they sell never list an Amp rating on their casing or insulator wrapping, just model number, a serial or batch number, and the nominal voltage rating 3.7v with the Mah rating. Just make sure to buy from a reputable source, as there are a lot of counterfeits out there.ġ) 35amps <- This is a dangerous rating, it is not the Continuous Discharge Rating being listed, but the Pulse Discharge rating, the difference between CDR and PDR is CDR is what the battery can sustain the whole discharge from fresh 4.2v charge down to 3.0v, PDR there is no set variables of what is a considered a max pulse time, it could be anywhere between 1/2 a second to 2 seconds, after that the battery has to shift down to CDR or overheat and potentially vent. If you want a bit more capacity the LG HG2s are perfectly good batteries that claim to be 3000 mAh (a bit less in my experience, but close enough.) Samsung and Sony also make good batteries in this range. With your usage you're actually more likely to have battery issues on the charger than while you're using your batteries in a decent regulated mod, I think. I'd also steer clear of batteries that claim a lot more than they deliver- that's a bad sign. honestly you can't be going through batteries that quickly, so I'd think that you'd do best to stick with good vaping batteries, which tend to top out at a claimed 3000 mAh. At 7.9 Watts (which is an oddly specific number- don't you change that at least a bit for different juice, etc?) you're not likely to stress a good battery much, and you could likely get away with a lesser battery (with maybe more mAh,) especially in a regulated mod, but. The thing you want to be a bit careful about (aside from buying good batteries) is the amperage you're pulling from the battery. Bold white foreground lines are packages that are currently installed and not changed and dim white are un-installed ones available but not installed. Red background lines are problems/warnings (but only if on something that needs to be installed or you want installed) Green lines are packages to be installed Purple lines are packages to be uninstalled and Cyan lines are packages (on the preview tab) that will be updated (on other tabs there will be a purple/green pair of lines). Use - t to access the menu and don't forget to do a - t U to update the package list (aptitude and apt-get are two separate utilities and each needs to have it's lists updated to keep their idea of what packages are around up to date.) Here is a capture of the information for that package on my Debian (Wheezy) PC (not a Pi!):Īny line in an aptitude tab beginning with - can be expended by selecting that line (with / arrows) and hitting and -\ lines collapsed in the same way. Download Gutenprint - Top Quality Printer Drivers for free. If that seems to be the case (the previous paragraph did not solve your problem) try running sudo aptitude - without any arguments aptitude runs as a text-mode application and it can show you the interrelation between packages and if there is a problem it offers an interactive means to fix things. Of course, that is tedious and not intuitive. The problem you are experiencing is that the extra package you have requested is later than the ones already installed but apt-get does not know (without running the "update" instruction) that new versions for all the interconnected packages have become available.!įailing that it may be that (temporarily) one or more packages have not been updated on the servers so that there is a mix of updated and un-updated both on the server and you have got a mix of both. You can help by testing this with your own printer and reporting the results Gutenprint 5.3. Still, it is possible to, for instance, 'install' a printer using a printer driver with gutenprint removed, then remove foomatic-db-engine, install gutenprint, and 'install' a printer using a gutenprint driver, and then re-install foomatic-db-engine, creating the proper set of ppd files. You have just done a: sudo apt-get update first haven't you (things can change on a daily basis) then try the sudo apt-get install cups-driver-gutenprint again. Full details: Description: Dai Nippon Printing DS-RX1 Location: Driver: Dai Nippon Printing DSRX1 - CUPS+Gutenprint v5.3. Creating the Gutenprint based printer driver. Im currently running CUPS 2.2.10 and I installed the printer using the Dai Nippon driver. It's still worth the install if you're a Tiger user, but the latest version requires at least 10.3 Panther.I would check that you really have an up-to-date list of packages available from the servers that you are using. Ive installed CUPS on it and Im trying to get the printer working with my Windows 10 machines. I have used Gutenprint for a while but failed to check if it was installed before I started using the package. Update: Thanks to Charley and Olligarski for commenting that Gutenprint drivers are now included in Leopard. ) and has made many users printers work and with this Printer Application these printers will continue to work in environments where only Printer Applications (and no classic printer driver packages) are supported. If you have an Epson Stylus Inkjet printer, you will then also be able to use "escputil" from Terminal to do printer maintenance like head aligning and cleaning. Gutenprint already ships for many years with most common Linux distributions (Ubuntu, Debian, Fedora, SUSE. All of the necessary PPD's and drivers will be copied to your computer, and you will be able to select Gutenprint drivers when adding printers. dmg (5.2.3 is the latest version) and install the package. So I installed the Gutenprint package, switched all printers to the Generic Gutenprint PCL driver, and the printing issues subsided. Right now, I can print to the printer and it works great, for 1 or 2 or 7 print jobs. The printer is attached via usb/parallel cable and I have successfully gotten it to print by building a custom PPD file starting from an HP LJ 2/gutenprint. I initially just used Leopard's built-in generic Postscript or PCL driver, but I had many issues with printing speed (the speed of spooling and job submission, not the speed of the physical printing process) and print quality. I have a Boca Model 44 ticket printer that I need to get working on a Mac running 'Mountain Lion'. Since I do a lot of Mac system imaging and deployment, I don't like to install a bunch of separate print drivers on a seed image. It has driver support for over 1300 printer models, and adds a GIMP plugin for better print customization and color adjustments. Gutenprint (formerly called Gimp-Print) is an open-source package of improved printer drivers and utilities that can be installed on Mac OS X to enhance printing functionality and add additional support for older printers. Studies using such ambiguous ABA- tone sequences have shown that perceptual splitting of sound events with different acoustic features into different streams increases over time ( Bregman, 1978 Anstis and Saida, 1985 Cusack et al., 2004). Generally, if alternations between two states exhibit independent durations with stationary statistics then the associated buildup function can be described by the statistical dynamics of an ARP. We propose that accumulation is not a necessary feature to produce buildup. Even though the competition model can show history dependence through slow adaptation, our statistical switching model, that neglects history, predicts well the buildup function. Our statistical-dynamics model describes well the buildup functions and alternations in simulations of pseudo-mechanistic neuronal network models with percept-selective populations competing through mutual inhibition. Using this theory, we describe the short-term dynamics of buildup observed on short trials in terms of the long-term statistics of percept durations for the two alternating perceptual organizations. In our model, perception alternates during a trial between different groupings, as in perceptual bistability, with random and independent dominance durations sampled from different percept-specific probability distributions. We present a statistical model based on an alternating renewal process (ARP) that generates buildup functions without an accumulative process. During long duration stimuli perception may alternate between integration and segregation. The buildup function has been said to reflect an underlying mechanism of evidence accumulation or adaptation. In behavioral experiments, when a subject's reports of stream segregation are averaged over repeated trials, one obtains a buildup function, a smooth time course for segregation probability. For example, segregation of acoustic features into streams may require several seconds. Then abruptly, perhaps after a few seconds, a segregated percept emerges. Initially, all stimulus features seem integrated. 3Department of Biology, New York University, New York, NY, USAįor some ambiguous scenes perceptual conflict arises between integration and segregation.2Courant Institute for Mathematical Sciences, New York University, New York, NY, USA.1Center for Neural Science, New York University, New York, NY, USA.Steele 1 *, Daniel Tranchina 2,3 and John Rinzel 1,2 Verification: It involves static analysis technique (review) done without executing code.Sara A. The V-Model is often used in safety-critical systems, such as aerospace and defense systems, because of its emphasis on thorough testing and its ability to clearly define the steps involved in the software development process.Maintenance: In the maintenance phase, the software is maintained to ensure that it continues to meet the customer’s needs and expectations.Deployment: In the deployment phase, the software is deployed and put into use.Testing: In the testing phase, the software is tested to ensure that it meets the customer’s requirements and is of high quality.Implementation: In the implementation phase, the software is actually built based on the design.Design: In the design phase, the software architecture and design are developed, including the high-level design and detailed design.Requirements Gathering and Analysis: The first phase of the V-Model is the requirements gathering and analysis phase, where the customer’s requirements for the software are gathered and analyzed to determine the scope of the project.The V-Model is a linear and sequential model that consists of the following phases:
# repositories and types from one server installation. # are repository servers and will give you the ability to manage multiple # Chocolatey Software recommends Nexus, Artifactory Pro, or ProGet as they # generally really quick to set up and there are quite a few options. # You'll need an internal/private cloud repository you can use. Internal/Private Cloud Repository Set Up # # Here are the requirements necessary to ensure this is successful. Your use of the packages on this site means you understand they are not supported or guaranteed in any way. With any edition of Chocolatey (including the free open source edition), you can host your own packages and cache or internalize existing community packages. Packages offered here are subject to distribution rights, which means they may need to reach out further to the internet to the official locations to download files at runtime.įortunately, distribution rights do not apply for internal use. If you are an organization using Chocolatey, we want your experience to be fully reliable.ĭue to the nature of this publicly offered repository, reliability cannot be guaranteed. Human moderators who give final review and sign off.Security, consistency, and quality checking.ModerationĮvery version of each package undergoes a rigorous moderation process before it goes live that typically includes: If you face any issues or have any questions, please comment below.Welcome to the Chocolatey Community Package Repository! The packages found in this section of the site are provided, maintained, and moderated by the community. Hope this guide helps you to enjoy Amazon Chime on your Windows PC or Mac Laptop. Double-click the app icon to open and use the Amazon Chime in your favorite Windows PC or Mac.
There two kinds of people in the world: Those who value smoothness and the more silent nature of linear switches, and those who want to watch hear the world burn.Ĭherry MX Red switches tend to be much more silent than other switch types. Red and Blue noise types are also on the opposite end of the spectrum and are again more up to preference and usage environment. The strong bump might now be for everyone, but is great for those who enjoy the feedback. With every press and every click, constant tactile feedback can improve your typing and make it a more enjoyable experience. When you have two different types of feedback, both tactile and audible, it helps to limit mistakes and bring you into the zone. You can read more about the best switches for gaming, if you are interested.īlue switches feature a prominent snappy bump on each keystroke followed by a clicking noise. Its strengths are also its weaknesses here, as the lack of a tactile bump can be better for gaming and provides a very clean and consistent experience. There is nothing to distract you from typing or the work ahead of you, be that typing or gaming.ĭue to the lack of a bump, you may be more likely to make errors and for that reason could slow you down when typing. Red switches are a smooth linear switch meaning it feels consistent and without tactility. We’ll explain the main differences in the feel so you can decide for yourself which type is better. When looking at feel, it’s impossible to assign a clear winner because it comes down to personal preference. If you’re a typist with a loud personality that values feedback and accuracy while typing, choose the Blues. While red switches may feel and sound better for certain uses, the light spring and lack of feedback make it more difficult to achieve the accuracy and speed that many typists need, especially writers and coders. This doesn’t mean you can’t type well on Red switches, rather it may take more practice to get comfortable and confident with such light linear switches. While your office-mates certainly won’t be happy, that’s what headphones were made for! With many of the same qualities as classic typewriters, Cherry MX Blues are the consensus when it comes to typing for both accuracy and satisfaction. Since typing became a popular profession and required skill for many careers, the tactile click has been right there wit If you’re a gamer that wants a light and predictable switch that will get you the performance you need without all the distractions, go with the Reds. While Blues will give you the feedback to confirm your key-presses and commands, the Red is the clear victor when it comes to practicality. Red switches, especially lubed Reds, will be a much more ideal choice for your stream. In addition, nowadays, many gamers are also streamers. If you need to be able to hear everything in the game, you don’t need to be hearing incessant clicking on top of everything else. The Cherry MX Red switch is the clear winner here. What you need is a smooth and silent option that is both dependable and predictable on every key-press, regardless of if you are calm or hyped up. When you are in “the zone”, and your team and score are relying on you, the last thing you need is a distraction. Let’s see how the switches perform in each category (feel, sound, gaming, and typing) and assign a winner. Red switches are super smooth and are relatively quiet, while Blue switches have a bump and are very loud. The main difference between the two switches comes down the feel and sound. Cherry MX Red vs Blue ColorĪ snappy bump and click on each keystroke. Let’s take a closer look at the differences between the two and decide which is a better fit for you. Now we have reached the pinnacle battle of the ages: Red vs Blue switches. The rivalry between the two switch types has raged on for millennia in one form or another. It also allowed the show to expand releases to a weekly schedule. The Season Pass Program has been successful in not only sustaining the show, but also in allowing David Cummings to focus full-time on production. This is unique in that fans of the show (referred to as the "Sleepless") who are not a part of the program still receive free access to shorter versions of each episode, generally consisting of the first one or two stories, as they’re released. Just before the release of its 3rd Season The NoSleep Podcast unveiled the Season Pass Program, whereby listeners pay a one-time subscription fee each season to have access to 25 full length episodes, in addition to a selection of subscriber-exclusive bonus episodes. As the quality of the show increased, expanding from a 30-minute format to over two hours per episode, the show announced that it had become unsustainable without outside funding. The NoSleep Podcast began as a volunteer endeavor, with all expenses being paid for out of pocket by its core team. Special guests that have appeared on the podcast include Mike Flanagan, Kate Siegel, Samantha Sloyan, Elijah Wood, and Kurtis Conner. The NoSleep Podcast is also one of the few podcasts in its genre that pays its creative contributors. Grim, “What Happens When the Stars Go Out” by Jesse Clark, and “Psychosis" by Matt Dymerski. The NoSleep Podcast has also featured stories from authors who have gone on to publish their works, including the “ Penpal” series from Dathan Auerbach, “99 Brief Scenes from the End of the World” by T.W. In 2015, the podcast was downloaded 600,000 times. Every year the show also produces a new collection of the flash stories in their “Suddenly Shocking” series and a retro radio drama series, “Old Time Radio”. New episodes typically air every Sunday and contain five or six stories per episode, not including bonus releases. The show also works with a number of artists to create original illustrations for each episode. The NoSleep Podcast theme was written by David Cummings and has evolved with each season of the show. Self-taught composer Brandon Boone, who joined The NoSleep Podcast in 2013, became responsible for the majority of the show’s music by Season 5. Despite horror arguably being a traditionally male-dominated genre, many of the narrators and authors of stories featured on the show, and also half of its 2 million regular monthly listeners are female. Regular voices on the show who provide narration for its stories include David Cummings, Jessica McEvoy, Peter Lewis, Nikolle Doolin, Nichole Goodnight, David Ault, Jeff Clement, Erika Sanderson, Addison Peacock, Mike DelGaudio, Atticus Jackson, Dan Zappulla, James Cleveland, Elie Hirschman, Kyle Akers, Alexis Bristowe, Jesse Cornett, Mick Wingert, and Erin Lillis. The popularity of The NoSleep Podcast rapidly grew as the production quality became more professional. During their first two seasons, David Cummings assumed the role of host and producer, working with volunteer Redditors to help narrate and produce content for the show. The idea was well received and a few months later a small group of members released the first episode of The NoSleep Podcast. With the popularity of NoSleep, a member named Matt Hensen proposed the idea of creating a podcast where the top stories from the NoSleep subreddit would be narrated in an audiobook style. NoSleep began as a subreddit, or forum, on Reddit where people would exchange scary stories and frightening experiences. The NoSleep Podcast is an anthology horror fiction podcast. Olivia White (Creative Content Manager). The Clone tool allows you to back up volume or the entire drive. What you do should a problem show up is up to you, but at the very least, you will be warned to back the drive up before it crashes all together. The Integrity Check enables you to locate problems before they locate you at a crucial moment. I would have to run Drive Genius off the disc to be able to do that. Note that my boot drive is not available. The Repartition, allows you to add, delete, hide, expand or shrink OSX partitions for more optimal organization of your hard drives.Īn excellent graphic layout provides clear and specific illustration of your drive utilization. Repair, which works just like the Repair Permissions in your Utilities folder but is said to be able to find errors that Disc Utility may not. It is also an excellent way to locate ancient files or documents just taking up hard drive space and reclaim that space for more necessary purposes. It also finds files that you haven't used in a long period of time that you may consider removing.ĭrive Slim can be quite useful for dumping all the languages you have installed and might never need. While I will not report on each tool's personal use, in addition to the Defragment tool, there is Drive Slim whose purpose is to free up space on your hard drive with duplicate, large file, language support and removal. The disc in the window never stops spinning as the defrag percentage counts down along the progress bar. More than likely running the defragmentation tool on your boot drive which is filled up with applications, plug ins and other necessary data would be expected to be practically a whole day affair so I would recommend running it either overnight while you sleep or on a day that you will not need to use the computer for other purposes. That's less than the 500 gig internal drive I used for several Final Cut Pro projects. Interestingly enough, after booting from the Drive Genius 2 DVD itself intending to defrag the 750gig boot drive, the defragmentation process took 3 hours, 12 minutes. This 500gig drive has seen plenty of trouble free use. Of course, the time it might take you would be dependent upon how much was in the drive and its frequency of use. That's a total of 3hrs, 48 minutes for this drive. My test started at 6:32 pm and by 7:55 it was 42% completed, by 9:06 it was getting there at 73% and just as I walked back into the room at 10:20 pm it finished with 100%. Actually, they are doing you a favor, as this is a good reminder that you should have a backup of all data before doing anything.ĭon't let it scare you, just remember to clone and back up anything you can't risk losing.Ī test utilizing the defrag tool from the Drive Genius 2 installed application on an internal 500 gig extra drive showed me that defragging remains a very time consuming process. It took a few minutes to boot up but all went well.Īt first a scary screen opens up warning you that possible data loss may occur. This is done by inserting the disc, doing a restart while holding down the C key until it boots off the disc. If defragging your boot drive, you would need to do this off the disc and not the installed application should you have previously installed it. In the maintenance section you have available the ability to defragment either your boot drive or any of your externals. The whole interface of Drive Genius 2 is plain cool to look at even when running any of the different tools.ĭespite current popular believe, hard drives can get fragmented as files grow and shrink. Should you launch a particular tool, a new window opens up allowing you to specify the hard drive you want to work on. Bringing your mouse over any of the icons brings it quickly forward with the icons name. There are two pages of possible tools divided into the 3 categories of maintenance, management and optimization. When first installed, either off the Drive Genius 2 DVD, or directly off your hard drive, a unique, graphical, animated interface comes up. Prosoft's Drive Genius 2 is like a Swiss Army knife of maintenance tools which comes equipped not only to more efficiently maintain your hard drives but also to provide management and optimization tools. At the same time, this maintenance can speed up your computer making things run more efficiently. By regular hard drive maintenance, you protect your disc from failing and losing important data. No longer is this as necessary as it was but your data is really only as safe as the condition of your hard drive and while the regular use of the Disc Utility found in your Applications/Utility folder keeps things in good working condition, a more complete and powerful tool may be in order. I recall the days of the G3, and earlier, when I would defrag the hard drive every other week and the time it took to do that. Apple has certainly made it easier over the years to maintain your computer's performance. This lipid disorder is characterized by xanthomas, elevated plasma cholesterol and triglyceride levels, and is associated with premature atherosclerosis in humans and experimental animal models of the disease. Homozygosity for the apoE2 isoform, which has defective in vitro binding capacity to the LDL receptor, is present in the vast majority of subjects with type III hyperlipoproteinemia (HLP). In apoE3 and apoE2 Arg-61 and Glu-255 do not interact. This orientation allows Arg-61 to form a salt bridge with Glu-255 in the C-terminal domain. In apoE4, the N- and C-terminal domains interact differently than in the other isoforms, since Arg-112 results in the orientation of the Arg-61 side chain in the N-terminal domain of apoE4 away from the four-helix bundle. The C-terminal domain is highly α-helical, as determined by computer modeling and circular dichroism spectroscopy, ,, but its exact structure is unknown. X-ray crystallography studies showed that the N-terminal domain is folded into a four-helix bundle of amphipathic α-helices spanning residues 24-164 that are stabilized by hydrophobic interactions and salt bridges. Digestion with thrombin produces a 22-kDa N-terminal fragment (residues 1 to 191) and a 10-kDa C-terminal fragment (residues 216 to 299). In the lipid-free state apoE is folded into two independent structural domains. ApoE4 is a major genetic risk factor for late-onset Alzheimer's disease. ApoE3, the most common form, contains cysteine at position 112 and arginine at position 158, whereas apoE2 has two cysteine residues and apoE4 has two arginine residues at these two positions. ApoE contains 299 residues and has three common isoforms (apoE2, apoE3, apoE4) in the general population, each differing in the amino acid positions 112 and 158. ApoE is also involved in cholesterol efflux processes, and thus may contribute to cell and tissue cholesterol homeostasis. Additionally, apoE interacts with other members of the LDL receptor family and cell-surface heparan sulfate proteoglycans (HSPGs). ApoE mediates the hepatic clearance of lipoprotein remnants from circulation serving as a ligand for the low-density lipoprotein (LDL) receptor. Apolipoprotein E (apoE) is a major protein of the lipoprotein transport system that plays critical role in the protection from atherosclerosis and dyslipidemia. |
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